Sensor and Microstructure Functionalization
Micro and nano sensing devices are used to rapidly detect minute quantities of analytes within very small sample volumes without the need for secondary reporter molecules. They have demonstrated value for applications in medicine, food safety, environmental science, and defense. Sensor miniaturization delivers a number of benefits, including a reduction in analyte sample volumes, an increase in the number of targets detected, and improvements in selectivity and sensitivity. Dip Pen Nanolithography® (DPN®) technology can easily functionalize sub-10 micron sensing areas with chemically or biologically active materials (such as enzymes, antibodies, DNA fragments, or inorganics). DPN has been proven to successfully functionalize a broad range of sensors, including those based on micro cantilevers, field-effect transistors (FET), nanowires, acoustics, optics, plasmonics and electronics. NanoInk’s DPN systems can also be used to functionalize microstructures such as microfluidic channels, PDMS structures, plastics, membranes, photomasks and many optical and electronic sensing devices.
Problems, Challenges & Un-Met Needs
Although sensing devices created using traditional fabrication platforms are robust, there are often technical hurdles involved in functionalizing the miniaturized elements - often with multiple materials. Similar difficulties are involved when constructing optical or electronic sensing devices by adding optical or electronic polymers or inorganic materials to specific areas on existing chips in a hybrid process. Until now, methods for easy, reliable, and multiplexed functionalization of miniaturized sensors have been lacking, yet these methods are necessary to advance into the realm of practical sensing applications.
Benefits of DPN
The NanoInk DPN platform is ideal for functionalizing miniaturized sensing devices for:
Yue, M.; Stachowiak, J. C.; Datar, R.; Cote, R.; Majumadar, A. Label-Free Protein Recognition Two-Dimensional Array Using Nanomechanical Sensors, Nano Letters 2008, 8, 520